Current Important Health Studies
Logo design by Dino Candelaria
OSA Mapping Project Status UpdateResearchers have been working very hard to collect sufficient number of cases and control dogs in the past few years. They are happy to report that they have just analyzed 155 OSA cases and 120 controls (Greyhounds) with the latest genome-wide screening technology. The results look very promising with one major gene and several additional genes contributing to the disease. Targeted sequence to find the actual mutations is currently ongoing. In parallel, two additional breeds, Rottweilers and Irish Wolfhounds, will also be analyzed this summer. To power these studies even more strongly, the researchers request more cases and controls from all three breeds. In addition, they would like dogs with osteosarcoma from all breeds since
they expect to examine many dog breeds for the presence of the Greyhound osteosarcoma mutations shortly. Therefore, please read on and learn how you can help them succeed in identifying mutations that give dogs the susceptibility for osteosarcoma.
How to participate in the cancer mapping projects:
Investigators are enrolling all purebred dogs that fall into any of the following categories:
1) Have been diagnosed with OSA
2) Over eight years old and without cancer
3) Have other types of cancer/hereditary diseases (see the comprehensive list at Dog DNA)
Researchers need 5ml (=1 teaspoon) of blood in a purple top tube (EDTA tube). The sample can be mailed in at room temperature, as long as it arrives within a week from the time it was taken. A consent form signed by the owner must be sent in with the sample. The consent form can be found at Dog DNA
along with more detailed instructions.
You can also contact the investigators by e-mail dog-info@broadinstitute.org. If you are also able to donate a sample from your dog's tumor in addition to the blood please contact the Modiano lab at the University of Minnesota by emailing Mitzi Lewellen (lewel001@umn.edu), call the lab (612-626-6890), or email the website contact lab@modianolab.org. All samples sent to Dr. Modiano's lab will be shared with the Broad Institute and with Dr. Matthew Breen's
laboratory at North Carolina State University.
All the information regarding your dog is kept strictly confidential, and the genetic disposition of any dog will never be made public. We are looking forward to your participation!!!
Click here for additional information about the active research the CHF has funded.
You can help by providing financial support to the AKC Canine Health Foundation's efforts; click here to make a secure online donation and please consider a recurring gift.
Contact:
Erika Werne
Director of Education & Communications
AKC Canine Health Foundation
